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The study was performed at two investigational sites

Also, xCT is mainly responsible for cystine/glutamate exchange and highly specific to Cys and glutamate ( c is inhibited, the production of GSH is decreased and the level of ROS and lipid peroxidation is increased, thereby leading to the occurrence of ferroptosis ( Glutathione exists in two formsreduced (GSH) and oxidized (GSSG)and the ratio of the two forms (GSSG/GSH) indicates the degree of oxidative stress in cells (Figure 3)

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2 Clinically, tinnitus is not recognized as a distinct disease entity, but rather as a heterogeneous symptom arising from various pathologies of the auditory system, including otitis media, Menieres disease, and sensorineural hearing loss (SNHL)